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Symbol
Name
ID 		Clec7a
C-type lectin domain family 7, member a
MGI:1861431
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgE level
Cutaneous anergy
Hypereosinophilia
Abnormal B cell count
Abnormal proportion of CD4-positive T cells
Abnormal proportion of CD8-positive T cells
Abnormal natural killer cell count
Recurrent aphthous stomatitis
Blepharitis
Lymphadenopathy
Hepatitis
Recurrent urinary tract infections
Abnormality of the immune system
Seborrheic dermatitis
Chronic mucocutaneous candidiasis
Chronic oral candidiasis
Recurrent vulvovaginal candidiasis
Skin rash
Immunodeficiency
Chronic tinea infection
Candida esophagitis
Phaeohyphomycosis
Recurrent infections
Onychomycosis
Recurrent respiratory infections
Recurrent viral infections
Meningitis
Deep dermatophytosis
Disease(s) Associated with CLEC7A
chronic mucocutaneous candidiasis

Mouse Phenotypes
immune system phenotype
impaired macrophage phagocytosis
abnormal neutrophil physiology
abnormal macrophage physiology
abnormal circulating interleukin level
decreased circulating interleukin-17 level
abnormal dendritic cell physiology
abnormal cytokine secretion
decreased tumor necrosis factor secretion
abnormal inflammatory response
lung inflammation
increased susceptibility to fungal infection
Availability Mouse Genotype
Clec7atm1Gdb/Clec7atm1Gdb
Clec7atm1Yiw/Clec7atm1Yiw *
Clec7atm1.1Bpip/Clec7atm1.1Bpip
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory